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In obese individuals, macrophages enter a pro-inflammatory state known as M1 polarization, which contributes to chronic inflammation

Among them, mesenchymal stem cells (MSCs) are regarded as ideal candidate cell types for achieving intervertebral disc regeneration due to their immunomodulatory properties and multidifferentiation potential

Therefore, we are unable to provide numerical equivalents for the standards at this time

4.4 Interaction and network integration of mechanisms: from independent pathways to systemic homeostasis It must be emphasized that the aforementioned three core mechanismsinflammatory regulation, antioxidant defense, and immunometabolismdo not operate in isolation during the pathophysiological process